Research
Traditional use and research
Reishi is lingzhi in Chinese and reishi in Japanese. It appears in Chinese herbal texts going back about two thousand years, where it was prized enough to be called the mushroom of immortality and carved into art and furniture. It was rare in the wild, so until modern cultivation began in the 1970s it was expensive and mostly reserved for the wealthy.
Two groups of compounds get most of the attention: triterpenes, including the ganoderic acids that give reishi its bitterness, and beta-glucan polysaccharides from the cell walls. In lab and animal studies these affect immune cells and inflammation.
Human evidence is thin. Clinical trials have been small, short, and mixed, and systematic reviews have concluded there is not enough evidence to recommend reishi for treating any condition, including cancer. Most people tolerate it well; the most common complaints are dry mouth and an upset stomach. It may add to the effect of blood thinners and blood-pressure medicines, and a few cases of liver injury have been reported with powdered reishi products.
Talk to a doctor before using reishi if you are pregnant, take blood thinners or blood-pressure medication, have a bleeding disorder, or have surgery coming up.